COMPARATIVE RESEARCH OF CHEMICAL PROFILING IN DIFFERENT PARTS OF FISSISTIGMA OLDHAMII BY ULTRA-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETRY

Comparative Research of Chemical Profiling in Different Parts of Fissistigma oldhamii by Ultra-High-Performance Liquid Chromatography Coupled with Hybrid Quadrupole-Orbitrap Mass Spectrometry

The roots of Fissistigma oldhamii (FO) are widely used as medicine with the effect of dispelling wind and dampness, promoting blood circulation and relieving pains, and its fruits are considered delicious.However, Hakka people always utilize its above-ground parts as a famous folk medicine, Xiangteng, with significant differences from literatures.S

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Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of ANARCHY WHITE GRAPE psoralen-based drugs whose mechanism of action is not fully understood.Here we provide evidence for a physical interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respiratory chain and show that this prox

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